The Computer Science and Engineering department at Loyola College, Chennai, established in 2010 through a partnership between Loyola College Society (LCS) and ICAM, France, focuses on providing technical education to the underserved communities. Offering a 60-student undergraduate program annually, the department actively collaborates with industries, facilitating student exposure and bridging the academia-industry gap.

Faculty and students have developed and maintained various software applications, including Performance Evaluation System, Apps for Education, Learning Management System (Moodle), and campus-wide networking activities. National-level technical events like Oracle Technology Network Yatra and Srinivasa Ramanujan Mathematical Competition are organized. The department manages G-Suite for education, offers Red Hat Academy certification programs, and engages in initiatives like NMEICT, Faculty Development Programmes, and Aakash R&D, receiving a grant of around 20 lakhs.

Students have excelled in innovative projects such as Project AR Labs, Implantable Hearing Machine, and Project MicrOS. Noteworthy contributions include software for campus management, attendance helpline, and online tests. Alumni find placements in leading companies like Infosys, Tech Mahindra, SAP, and Vernalis. Through the ICAM MoU, 10 to 15 students, accompanied by a faculty member, annually undertake technical projects at ICAM campuses in France.

The department of Computer Science and Engineering has been recognized as a research centre for collaborative research with Anna University and to guide Ph.D scholars to carry out research in their area of interest.